Organic Chemistry 1

Learner's Feedback:

"This course is very great and is helpful not only for students but also for all chemistry professors. This course is the best platform for all organic chemistry learners. The language is very easy. So that, each and every student can understand all the concepts easily. Discussion forum is also a best platform for us to ask any query about any concept.
Thank you very much sir for excellent teaching, clearing every concept in organic chemistry from basic and giving assignments to us. Keep it up sir.
Also,thanks to SWAYAM for conducting such type of course for all chemistry learners." ---- Ketaki, One of the topper from the course July-2019.
"The classes are very explanatory and very useful for the PG students and also for the faculty members. I really appreciate the efforts taken by Balaji sir. " ---Seethalakshmi S "The course content was so relevant and insightful that every individual would definitely benefit hugely from it for their career in chemistry. The classes are very vivid, crystal clear and knowledgeable. I am very fortunate to be part oc this course." ---- Ramakrishna S "Professor Balaji did spendid job and did lots of efforts. Its been 15 days to the course have started and I am taking it right now. This course is beneficial to all as the professor took the course from basics to advance, this make learning very easy & he is very responsive which makes it very convenient." ----- Simran K "very good nd well qualified professors.
for solving gate, net questions, dis course iz useful. thanku for efforts of all professors". ---- Anonymous Syllabus Week 1

Introduction to stereochemistry Conformational analysis of open chain systems

Week 2

Conformational analysis of cyclic systems Symmetry elements, Point group analysis Stereochemical conventions

Week 3

Stereogenicity, Topicity ORD and CD, Axial halo ketone rule, Octant Rule

Week 4

Stereochemical reactions Reactions involving stereo centres Crams Rule, Felkin-Anh model, Prelog rules

Week 5

Aromaticity, Aromatic stabilization energy, Hückel MO, Musulin-Frost diagram Polycyclic aromatic hydrocarbon (PAH), Polyacenes, Annulene

Week 6

Aromatic Electrophilic substitutions Aromatic Nucleophilic substitutions Ipso-cine-tele substitution

Week 7

Reaction dynamics, Hammond postulate Linear free energy relationship, Hammett equation

Week 8

Yukawa Tsuno equation, Swain-Lupton equation, Grunwald–Winstein equation, Taft equation Curtin-Hammett principle, Winstein-Holness equation

Carbocation, Part 1: Generation, Structure and Geometry

Week 9

Carbocation, Part 2: Stabilisation of carbocation, Reactions

Carbocation, Rearrangement 1: No Change in carbon skeleton, Change in carbon skeleton

Carbocation, Rearrangement 2: involvement of other electron deficient terminus, Anchimeric assistance

Week 10

Carbanions: pKa and its significance

Carbanions: Hard and Soft Acid and Base principle

Carbanions: Structure, Formation, Stability, Reactivity

Week 11

Carbanion reactions: Acyl Anions, Benzoin condensation, Umpolung-inversion of reactivity

Free radical 1: Formation, Structure, Stability

Week 12

Free radical 2: Stability, Reactivity Free radical 3: Reactions: Addition, atom abstraction, disproportionation, cyclisation

Week 13

Free radical 4: Reactions: Fenton, Kolbe, Bouveault-Blanc, Giese, Hofmann-Loffler, Birch, Barton-McCombie, Sandmeyer, Barton decarboxylation Carbene, Nitrene: Generation, Structure, Reactivity

Week 14

Carbonyl addition reaction Enol and enolate formation and reactions

Week 15

Enol ethers formation and reactions, Mukaiyama-Aldol reaction Sharpless epoxidation, Click reaction, Diels-Alder reaction- Scope and mechanism

Exam