This course provides detailed insight of the field of optical biosensors and their basic working principles. Staring with the introduction of basic components, characteristics, performance parameters and fabrication techniques (lectures 1&2), this course brings the learner to the mesmerizing field of sensors based on basic principles of optics. The basic optical phenomena/characteristics and their sensing applications have been discussed in detail (lectures 3-8). In the last two lectures, the optical properties of tissues and optics in the biomaterials has been discussed with providing some further insights into optical biosensing applications. The course ends with notes on terahertz sensing applications and future directions of research.
INTENDED AUDIENCE : Physics, Nanotechnology, Biosciences, Electrical Engineering, Electrooptic Engineering, Photonics
PREREQUISITES : Basic knowledge of Optics (Geometrical optics, Interference, Diffraction, polarization, etc.)
INDUSTRY SUPPORT : Photonic Sys
Week 1 : Lecture 1: Introduction to sensors and biosensors:Characteristics and components of optical biosensors,various
transduction mechanisms, Optical probing parameters
Lecture 2: Performance parameters, Fabrication and functionalization methods of optical biosensors
Lecture 3: Basic optics for optical biosensing-I:Electromagnetic waves in free space: –Maxwell’s equations,
EM Wave equations, Power density, Polarization, Scattering
Week 2 : Lecture 4: Basic optics for optical biosensing-II: Electromagnetic waves in matter Dielectrics, Reflection
and transmission at interface: Fresnel equations, Polarization by reflection – Brewster angle sensor
Lecture 5: Basic optics for optical biosensing-III: Electromagnetic waves in matter Total internal reflection- TIR sensors,
Evanescent wave sensing, factors affecting performance, importance of penetration depth, waveguide sensors using TIR
Lecture 6: Basic optics for optical biosensing-IV: Electromagnetic waves in matter Absorption and dispersion,
conductors: Drude model for the metal dielectric function and introduction to plasmons
Week 3 : Lecture 7: Plasmonic sensors: Propagating versus localized plasmons, Optimized sensor configurations, Electromagnetic
field enhancements, plasmon enhanced sensors
Lecture 8: Basic optics for optical biosensing-V: Interference and diffraction Interference and interferometry, Airy function for
single layer, Mach Zehnder Interferometer for sensing, Fabry Perot Interferometer for sensing.
Week 4 : Lecture 9: Review of biomaterial optics:Biomaterial Structures EM Waves Absorption in Tissue, Chirality, polarization
rotation and dichroism,
Lecture 10: Review of sensing applications: Scattering–Elastic (Rayleigh), –Inelastic (Raman); Fluorescence, Some real life
optical biosensors, Sensing at terahertz.