Biomolecules: Structure, Function in Health and Disease


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This course on Biomolecules is one of the basic course for all PG Students of Biological Sciences.
Gives an overview of importance of biomolecules starting from the simplese molecule, water.
Elaborate the need to study proteins: Their 3D Structure,protein seperation,sequencing etc.
To understand the pathology and identifying biomrakers using clinical proteomics.
Explain in detail DNA,RNA their structures, interactions role in disease,genomics.epigenetics.
Enumerate the role of carbohydrates,lipids and their cellular function in physiology and pathology.
To briefly introduce to system biology


COURSE LAYOUT SWAYAM Course Syllabus:Biomolecules: Structure Function in Health & Disease Week 1 Chemical bonds:Different types of Bonds, Bond energies,Bond Angles etc, Water:The molecule of life,Aqueous Solution,Acids & Bases,Measurements of pH, Henderson Haselbatch equation,Titration Curve & pK values,Buffers Week 2 Amino acids, chirality, peptide bond and polypeptides,Structural levels of proteins and Stabilizing forces,Conformational properties of polypeptides and Ramachandran plot Week 3 Turns, loops, Super secondary structures, motifs and domains in proteins,Structures and function of Fibrous Proteins,Structure and function of Actin and myosins Week 4 Hemoglobin, Myoglobin and Oxygen binding,Role of Protein Structure in Health and Disease,Assessment 1 Week 5 Protein Seperation Techniques: Centrifugation & Chromatography,Protein sequencing Week 6 Methods of structure determination of proteins : X-ray, NMR, CD etc,Clinical Proteomics Week 7 Antigen-Antibody Complex and their Applications in Immunology,Protein-Ligand(Small Molecules including drugs) interaction Week 8 Components of Nucleic Acids,Conformational parameters of Nucleic acids and DNA double helix,DNA Polymorphism Week 9 Circular DNA,Supercoil DNA Week 10 Interactions of small molecules (ions, drugs ) with DNA,Different types and structures of RNA Week 11 DNA-Protein interactions,Assessment 2 Week 12 Introduction to Carbohydrates,Structures of polysaccharides,Saturated and unsaturated fatty acids, Nomenclature of fatty acids and Essential and non-essential fatty acids Week 13 Glycoproteins and Proteoglycons,Classification of Lipids: simple and compound lipids, phospholipids, Cholesterol,Micelles and Liposomes : Applications in biology and medicine Week 14 Lipids: extraction, separation and analysis,Components and architecture of Cell membrane,Various membrane models including Fluid-mosaic model Week 15 Cholesterol and its role in health and disease,Interrealtionship of Biomolecules : System Biology,Epigenetics and Human Diseases,Final Assessment